Transmission of Mechanical Information by Purinergic Signaling

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Purinergic Signaling in Bone

1 Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, 2600 Glostrup, Denmark 2Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy 3 Bone Biology Laboratory, Department of Cell and Developmental Biology, University College London, London WC...

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The Modulation of Synaptic Transmission by the Glial Purinergic System

Accumulating evidence indicates that bioactive substances produced by glia play an important role in the modulation of synaptic transmission. Astrocytes and microglia express many types of P2 purinoceptors and the stimulation of these receptors causes the release of bioactive substances, termed “gliotransmitters”, such as ATP, glutamate and cytokines. Gliotransmitters are able to modulate synap...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2019

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2019.04.012